How to better and faster to stop hypertension condition?

Treatment of hypertension with different antihypertensive mechanisms of drugs, to play the maximum hypotensive effect of each drug. As a diuretic and B receptor blocker combined, diuretics can eliminate the B receptor blocker in long term application of water produced by the sodium retention, but can induce a pressor effect of renin secretion, and B receptor blockers in turn to mild inhibition of renin secretion, in addition to these two classes of drugs have the same or similar adverse reactions

The expert thinks, two kinds of hypertensive patients when initial therapy, should be combined with medication : one is the systolic blood pressure at 160 mm Hg above, two is associated with diabetes, renal vascular damage, cardiovascular and cerebrovascular disease risk factors in patients with essential hypertension.

In clinical, commonly used antihypertensive drugs in six categories, including diuretics, B receptor blockers, calcium channel blockers, angiotensin converting enzyme inhibitors ( ACEI ), angiotensin type II-1 receptor antagonist, a- receptor blockers. In the implementation of the joint application of antihypertensive agents, generally have the following requirements:

One, will have different antihypertensive mechanisms of drugs, to play the maximum hypotensive effect of each drug. As a diuretic and B receptor blocker combined, diuretics can eliminate the B receptor blocker in long term application of water produced by the sodium retention, but can induce a pressor effect of renin secretion, and B receptor blockers in turn to mild inhibition of renin secretion, in addition to these two classes of drugs have the same or similar adverse reactions, the price is very low, therefore is a good combination of drugs, often used in patients with mild and moderate hypertension, especially without obvious blood sugar, blood lipid, uric acid and metabolic abnormalities of the preferred drug combinations.

Two, two kinds of antihypertensive drugs, to eliminate the " compensatory effect ". When blood pressure drops, the body tends to produce a prevent further lowering of blood pressure response, the medical term for " compensation ", appropriate combination can eliminate this compensatory effect. If the long time use central antihypertensive drug clonidine, because of reduction of renal blood flow and glomerular filtration rate reduction, caused by retention of water and sodium, such compensation may limit the drug antihypertensive effect, then combined with diuretics can eliminate clonidine produced sodium and water retention, due to the synergistic hypotensive effect.

Three, two kinds of antihypertensive drugs, to reduce adverse reactions or side effects. Such as calcium channel blockers in antihypertensive and vasodilator, reflex induced by sympathetic arousal, increased heart rate, patients often feel nervous, if combined with B receptor antagonist, can use the heart rate effect, eliminate its adverse reactions accelerated heart rate. In addition, the ACEI class of antihypertensive drugs taken for a long time, there was mild elevation of serum potassium and sodium and water retention effect, when using the efflux of potassium diuretic drugs ( such as hydrochlorothiazide ), which can eliminate the retention of water and sodium balance, and blood potassium effect, therefore is a good combination of drugs.

Of course, if two antihypertensive drug adverse reactions to the same or similar unfavorable combined application. As of B receptor blockers are generally not associated with slow release verapamil combination, because after coadministration may cause severe atrioventricular block. B receptor blockers with sustained-release diltiazem has heart inhibition, although milder, but should be used with caution. Two row: potassium diuretic drugs such as hydrochlorothiazide or containing hydrochlorothiazide compound ( such as Zhenjujiangya tablets ) and indapamide ( combined indapamide ), can cause severe hypokalemia.

The combined use of antihypertensive drugs should be under the guidance of a doctor, in order to ensure safe, effective, both increased antihypertensive effect, but also can reduce adverse reaction.